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research Effect of perfluorooctanesulfonate exposure on steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis

4 citations , March 2019 in “JAT. Journal of applied toxicology/Journal of applied toxicology”

In this study, PFOS exposure altered steroid hormone levels and enzyme activities related to steroidogenesis in juvenile Silurana tropicalis, with effects differing between male and female frogs.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

This review discusses the pathways of androgen biosynthesis and reports no new findings, highlighting the need to understand the interplay between the classic and backdoor pathways.

research Topical Finasteride Therapy in Hirsutism

1 citations , January 2001 in “Endocrine Practice”

This study suggests that topical finasteride may benefit women with facial hirsutism, based on observations from a small sample.

research Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases

51 citations , May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology”

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that 11α-hydroxyprogesterone is a potent inhibitor of 11βHSD2 in vitro and may serve as a precursor to unique C11α-hydroxy steroids in prostate cancer tissue.

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community Thoughts about ORAL ketoconazole? (pills)

8 months ago

Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Pls advice needed. 17-20 yo. Not seeing the progress I hoped for on finasteride + minoxidil. Any advice?

in Progress Pictures 22 upvotes 6 months ago

A user is experiencing hair loss despite using topical minoxidil, oral finasteride, and 2% ketoconazole shampoo, and is seeking advice on further treatments. Suggestions include switching to dutasteride, trying oral minoxidil, addressing scalp inflammation, and considering dietary changes and supplements.

community Almost 20 Years on Finasteride - AMA

in Progress Pictures 837 upvotes 1 year ago

A user successfully halted hair loss using finasteride for 17 years and recently switched to dutasteride for stronger DHT suppression. They experienced no major side effects, maintained a full head of hair, and fathered three children without issues.

community 4 years apart (17-21) on treatment

in Progress Pictures 40 upvotes 4 months ago

A user shared their hair loss journey, starting treatments with topical minoxidil and finasteride at 17, and later adding oral versions and dutasteride by age 20, but still experiencing hair loss. Others suggested that the treatments have likely slowed the progression, and some recommended considering a hair transplant or adjusting medication, while expressing concerns about the potential side effects of starting such treatments at a young age.

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