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Glossary11β-Hydroxylase Deficiency

genetic disorder causing hormone imbalances and adrenal gland dysfunction

11β-Hydroxylase Deficiency is a genetic disorder that affects the adrenal glands, leading to an imbalance in hormone production. Specifically, it results in reduced levels of cortisol and aldosterone, and an excess of androgens, which can cause symptoms like high blood pressure, early puberty, and ambiguous genitalia in newborns. This condition is a form of Congenital Adrenal Hyperplasia (CAH).

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11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , July 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research Intracrine androgen biosynthesis, metabolism and action revisited

131 citations , April 2018 in “Molecular and Cellular Endocrinology”

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

research Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome

40 citations , May 2016 in “The Journal of Clinical Endocrinology & Metabolism”

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

research ENZYMES

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Roux-en-Y gastric bypass in the treatment of non-classic congenital adrenal hyperplasia due to 11-hydroxylase deficiency

5 citations , March 2013 in “BMJ case reports”

Gastric bypass surgery improved a woman's hormonal disorder without the need for medication.

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