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11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that 11α-hydroxyprogesterone is a potent inhibitor of 11βHSD2 in vitro and may serve as a precursor to unique C11α-hydroxy steroids in prostate cancer tissue.

The Effect of the Antiandrogen 11α-Hydroxyprogesterone on Sebum Production and Cholesterol Concentration of Sebum

research The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum

27 citations , July 1982 in “British Journal of Dermatology”

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

research An Occult Leydig Cell Tumour in a Postmenopausal Woman Presenting with Alopecia and Hirsutism: A Case Report

3 citations , January 2021 in “touchREVIEWS in Endocrinology”

This case report describes how a 68-year-old woman's hyperandrogenic symptoms improved and testosterone levels normalized after the surgical removal of an occult Leydig cell tumour.

Endocrinology and Auxology of Siblings with Non-Classical Congenital Adrenal Hyperplasia

research Endocrinology and auxology of sibships with non-classical congenital adrenal hyperplasia.

13 citations , May 1996 in “Archives of Disease in Childhood”

This study found that patients with non-classical 21-hydroxylase deficiency do not appear to be at risk of short adult stature despite increased bone age in childhood.

Adrenal 21-Hydroxylase Gene Mutations in Slovenian Hyperandrogenic Women: Evaluation of Corticotrophin Stimulation and HLA Polymorphisms in Screening for Carrier Status

research Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status

19 citations , August 1999 in “European journal of endocrinology”

This study concluded that neither basal nor ACTH-stimulated 17-OHP concentrations effectively indicate carrier status for 21-hydroxylase deficiency among Slovenian hyperandrogenic women, recommending molecular analysis of the CYP21 gene for reliable screening.

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community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community 11 months on topical minoxidil, and four months on topical finastride

11 upvotes 2 weeks ago

The conversation discusses hair loss treatments using topical minoxidil (5%) and topical finasteride, with no side effects reported. Users share application tips and express hope for regrowing hair, especially in the corners and temples.

community 11 months of progress on 1.25 fin only.

14 upvotes 1 month ago

The user experienced improved hairline results after 11 months on finasteride, with no significant side effects except temporary nipple sensitivity. They are considering adding minoxidil for better results but are waiting for full effects from finasteride.

community 11.5-month progress on Finasteride + Minoxidil (Topical → Oral). Looking for honest opinions on what’s still possible.

213 upvotes 2 months ago

OP experienced significant hair regrowth using 1 mg oral Finasteride and switched from topical to 2.5 mg oral Minoxidil, with concerns about miniaturized hairs near the hairline. OP plans to grow out their hair and is curious about future regrowth potential and hairstyle suitability.

community 11 months on oral .25 min and .5 dut

164 upvotes 3 months ago

The user switched from finasteride to dutasteride and experienced hair regrowth with no side effects, using 2.5mg oral minoxidil and 0.5mg dutasteride. The user noticed improved mood due to more hair and found the treatment effective, starting at age 21.

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