Challenges in Diagnosing Ovarian Sertoli-Leydig Cell Tumors: A Peruvian Case Series
September 2024
in “
Electronic Journal of General Medicine
”
Studysummary In this case series study, two Peruvian women with virilizing ovarian tumors called Sertoli-Leydig cell tumors showed clinical improvement and normalization of androgens after surgical treatment, highlighting the diagnostic challenge of these rare presentations at different ages.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case series discusses the challenges in diagnosing Sertoli-Leydig cell tumors (SLCT) in two Peruvian women with virilization symptoms. The first case involved a 27-year-old woman with polycystic ovary syndrome (PCOS) who experienced voice changes, increased muscular strength, and acne, leading to the discovery of SLCT after a left salpingo-oophorectomy. The second case involved a 48-year-old woman with a history of PCOS, prediabetes, and dyslipidemia, who presented with hirsutism, alopecia, and other symptoms, resulting in the identification of SLCT following a bilateral salpingo-oophorectomy and hysterectomy. Both cases showed normalization of androgens and clinical improvement post-surgery. The study highlights the diagnostic challenges due to the unusual presentation of SLCT, which can occur at any age with rapidly evolving hyperandrogenism and virilization symptoms.
