Successful Treatment of Perifolliculitis Capitis Abscedens et Suffodiens With Combined Isotretinoin and Dapsone
October 2007
in “
JDDG Journal der Deutschen Dermatologischen Gesellschaft
”
Studysummary In this case study, combination therapy with dapsone and isotretinoin significantly improved perifolliculitis capitis abscedens et suffodiens, with the patient remaining symptom-free for six months on reduced medication.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Perifolliculitis capitis abscedens et suffodiens (PCAS) is a challenging scalp condition often associated with scarring alopecia and other skin issues. A 19-year-old male patient with a 2-year history of PCAS did not respond to various antibiotic treatments or surgery. Initial monotherapy with isotretinoin was ineffective. However, a combination therapy of isotretinoin (80 mg daily) and dapsone (100 mg daily) led to significant improvement within 4 weeks. After 6 months, dapsone was reduced to 50 mg daily, and isotretinoin was gradually discontinued. The patient continued on dapsone 50 mg every other day and remained symptom-free for 6 months.
