A Case of Widespread Actinic Granuloma with Associated Drug-Induced Lupus Erythematosus

In the document, a case of a 71-year-old male with a sudden onset of a widespread pruritic eruption of annular plaques is reported. The plaques were distributed in areas exposed to sunlight, and the patient had recently started taking hydralazine. Initial diagnosis suggested hydralazine-induced lupus due to the clinical presentation, biochemical investigations, and skin biopsy. However, the biopsy revealed actinic granuloma, a rare skin disease triggered by an immune response to modified elastic tissue antigenicity. This case is notable because actinic granuloma and drug-induced lupus erythematosus are rarely associated, emphasizing the importance of biopsy in diagnosing photodistributed dermatoses and investigating potential systemic associations. No commercial support was identified for this case report.