Noninvasive Method for Assessing the Human Circadian Clock Using Hair Follicle Cells

August 2010 in “ Proceedings of the National Academy of Sciences of the United States of America ”

Makoto Akashi, Haruhiko Soma, Takuro Yamamoto, Asuka Tsugitomi, Shiko Yamashita, Takuya Yamamoto, Eisuke Nishida, Akio Yasuda, James K. Liao, Koichi Node

hair follicle cells circadian clock gene expression biopsy samples peripheral circadian clock rotating shift workers

Studysummary This study reports a less invasive method for detecting human clock gene expression using hair follicle cells, which accurately reflects individual behavioral rhythms and suggests a time lag issue for rotating shift workers.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on pnas.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research The patch assay reconstitutes mature hair follicles by culture-expanded human cells

11 citations , July 2017 in “Regenerative Medicine”

This study found that the patch assay effectively reconstituted mature hair follicles using culture-expanded human fetal cells and may serve as a method to assess cell trichogenicity.

research Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells

15 citations , October 2012 in “Journal of circadian rhythms”

This study found that extracting RNA from equine hair follicles can effectively identify 24-hour oscillations of specific circadian clock genes, offering a valuable non-invasive method to evaluate the equine circadian clock.

Estimation Methods for Human Circadian Phase Using Peripheral Tissues

research Estimation methods for human circadian phase by use of peripheral tissues

14 citations , June 2016 in “Hypertension research”

The authors concluded that utilizing clock gene expression from hair follicle cells may improve circadian-phase estimation in clinical settings, aiding the detection of circadian-related sleep problems despite social time constraints.

research Illuminating microflora: shedding light on the potential of blue light to modulate the cutaneous microbiome

April 2024 in “Frontiers in cellular and infection microbiology”

This review highlights evidence supporting the potential of blue light therapy as a non-invasive treatment for managing skin and hair conditions by modulating interactions between the skin microbiome and its host.

research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

92 citations , September 2013 in “Journal of Investigative Dermatology”

This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.