Phytochemical Investigation of Vitex Negundo and Formulation of Oil for Hair Growth and Potential Alopecia Activity
January 2025
in “
International Journal of Pharmaceutical Research and Development
”
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Studysummary This study evaluated a herbal oil formulation in an animal model, finding it significantly enhanced hair growth initiation and completion times compared to a control, suggesting it as a natural and safer alternative to synthetic hair growth treatments.
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The study explores the use of Vitex negundo extract in formulating an herbal oil for hair growth and alopecia treatment. The ethanolic extract, rich in flavonoids and phenolics, was tested on rats, showing no toxicity up to 2000 mg/kg. The oil demonstrated significant hair growth, with initiation within the first week and full growth in 20-24 days. The F3 formulation's effectiveness was comparable to Minoxidil, working by inhibiting 5α-reductase and reducing DHT levels, which are associated with androgenetic alopecia. The study concludes that Vitex negundo offers a natural, safe alternative to synthetic treatments, though further research is needed to confirm its efficacy and safety in humans.
