The Role of Vitamin D3 Deficiency and Colonization of the Oral Mucosa by Candida Yeast-like Fungi in the Pathomechanism of Psoriasis

This review examines the potential role of vitamin D3 deficiency and Candida yeast-like fungi colonization in the pathogenesis of psoriasis, a chronic inflammatory skin disease affecting about 2% of the population. Vitamin D3 deficiency is associated with microbiological imbalances that may promote Candida overgrowth, potentially exacerbating psoriasis by modulating immune responses and increasing skin inflammation. The document highlights the importance of vitamin D3 in skin health and immune regulation, suggesting that antifungal treatments and vitamin D3 supplementation could offer new therapeutic pathways for psoriasis management. However, further research is needed to clarify these relationships and determine optimal supplementation doses. Additionally, the review notes that regular physical activity may benefit psoriasis patients by enhancing vitamin D3 levels and reducing inflammation.