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    April 2008 in “ Experimental Dermatology ”
    Ichiro Kurokawa
    TLDR Hidradenitis suppurativa may mainly affect vellus hair follicles, not terminal ones.
    The document discussed hidradenitis suppurativa (HS), likening its complex pathobiology to a labyrinth. Despite extensive research, the etiology of HS remained unclear, with conflicting hypotheses. The study questioned the role of terminal hair follicles in HS, suggesting instead that HS predominantly affected the infundibulum of vellus hair follicles. The document highlighted abnormalities in keratinization and proposed that sinus epithelium in HS might arise from epidermal invagination. It also considered the potential role of bacteria and immune responses in influencing HS's clinical phenotype. Future research was suggested to focus on infundibular immunology, keratinization, and epithelial adhesion to better understand HS pathogenesis.
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