Adverse Effects of Valproic Acid in Epileptic Infants and Adolescents

October 1993 in “ PubMed ”

M Devilat, J E Blumel

valproic acid hair loss serum alkaline phosphatase transaminases prothrombin time platelet counts

TLDR Valproic acid can cause mild side effects like anorexia and hair loss in some epileptic patients.

This study examined the adverse effects of valproic acid in 100 epileptic patients aged 7 months to 19 years over at least 13 months. Clinical side effects were observed in 14% of patients, with anorexia and hair loss being the most common. Laboratory findings showed elevated serum alkaline phosphatase and transaminases in one-third of patients, while 4% had lower prothrombin time and 1% had low platelet counts. One patient had persistent low platelet counts even after stopping the drug, but a causal link could not be established due to missing baseline data. No correlation was found between adverse symptoms and valproic acid plasma levels. Despite the lack of baseline laboratory values and confirmation of abnormal tests, the adverse effects were not deemed severe, but caution was advised in using the drug.

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research Adverse Effects of Valproic Acid in Epileptic Infants and Adolescents

4 citations , October 1993 in “PubMed”

Valproic acid can cause mild side effects like anorexia and hair loss in some epileptic patients.