Utility of GLI1 RNA Chromogenic in Situ Hybridization in Distinguishing Basal Cell Carcinoma From Histopathologic Mimics

June 2023 in “ Modern Pathology ”

Tyler D. Menge, Joseph S. Durgin, Steven Hrycaj, Ashley A. Brent, Rajiv M. Patel, Paul W. Harms, Douglas R. Fullen, May P. Chan, Scott C. Bresler

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research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis

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GLI1 might protect against the start of skin cancer and is not linked to cancer severity.

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research Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

8 citations , January 2014 in “Annals of Dermatology”

The research suggests that p63 and TGF-β1 may help determine tumor type and malignancy in hair follicle and sebaceous tumors.

research GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter

171 citations , June 2004 in “Journal of Investigative Dermatology”

GLI2 activates GLI1, promoting skin tumor growth and hair development.

research Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.