Upregulation of mir-1199-5p is associated with reduced type 2 5-α reductase expression in benign prostatic hyperplasia

November 2022 in “ BMC Urology ”

Zhanliang Liu, Zhemin Lin, Fang Cao, Mingxin Jiang, Song jin, Yun Cui, YN Niu

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research Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride

30 citations , October 2020 in “Nature Communications”

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

research Structure of Human Steroid 5α-Reductase 2 with Anti-Androgen Drug Finasteride

4 citations , July 2020 in “Research Square (Research Square)”

The research helps understand how finasteride works and aids drug development.

research Reduced Levels of 5-Alpha Reductase 2 in Adult Prostate Tissue and Implications for BPH Therapy

39 citations , February 2011 in “The Prostate/The prostate”

Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.

research Estrogen and Androgen Signaling in the Pathogenesis of Benign Prostatic Hyperplasia

149 citations , January 2011 in “Nature reviews. Urology”

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.