Trichoblastic Carcinoma

The document reported on two cases of deeply infiltrative trichoblastic neoplasms, which showed histologic features of malignancy. The study involved a 53-year-old female and a 74-year-old male, both presenting with neoplasms in the lip region. The excised specimens revealed locally aggressive tumors with differentiation towards hair germ and follicular sheath, along with papillary mesenchymal bodies, follicular bulb-like structures, small keratin cysts, and rare malformed hair shafts. The neoplasms exhibited asymmetry and significant subcutaneous and muscular infiltration. The findings suggested the possibility of a distinct trichoblastic carcinoma, separate from basal cell carcinoma.