Mario Lacouture: How Do I Treat a Patient with Dermatologic Toxicities to EGFR Inhibitors?

In 2011, Dr. Mario E. Lacouture provided a comprehensive approach to managing dermatologic toxicities in patients treated with EGFR inhibitors, which are known to cause a range of skin-related side effects. He recommended prophylactic use of minocycline or a combined regimen including doxycycline, hydrocortisone cream, sunscreen, and moisturizer starting from the first day of therapy to reduce the severity and frequency of skin toxicities. For dry skin, he suggested using specific moisturizers and exfoliants, and for fissures, a maximum strength Desitin. He also recommended mupirocin ointment for nasal dryness and topical steroids for xerotic dermatitis. For paronychia, he advised topical treatments, vinegar soaks, and possibly silver nitrate cauterization. Itching was to be managed with oral antibiotics, topical steroids, anti-itch creams, and antihistamines. He also provided specific recommendations for the use of topical steroids on different parts of the body, including the face, body, and scalp. Dr. Lacouture emphasized the importance of managing these side effects to maintain the quality of life for patients undergoing cancer treatment.