Transethosomes: A Comprehensive Review of Ultra-Deformable Vesicular Systems for Enhanced Transdermal Drug Delivery

January 2025 in “ AAPS PharmSciTech ”

Raagul Seenivasan, Praveen Halagali, Devika Nayak, Vamshi Krishna Tippavajhala

The review provides a comprehensive analysis of transethosomes, ultra-deformable vesicular systems that enhance transdermal drug delivery by improving skin penetration, solubility, absorption, and stability of therapeutics. These systems combine the benefits of transferosomes and ethosomes, allowing for the encapsulation of both hydrophilic and hydrophobic drugs, and are applicable in various administration routes, including ophthalmic and transvaginal. Transethosomes have shown promise in treating conditions like psoriasis, skin cancer, and fungal infections, with studies demonstrating improved drug release and therapeutic efficacy. Despite challenges such as stability issues and potential skin irritation, transethosomes offer a versatile and scalable solution for enhanced drug delivery, with ongoing research exploring their broader applications beyond transdermal delivery.

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