Study on Toxicity of Hydrocortisone 17-Butyrate 21-Propionate: Subacute Toxicity in Dogs by Percutaneous Administration

    January 1981 in “ The Journal of Toxicological Sciences ”
    Yasuo Tarumoto, Takashi Sakagawa, Yoshifumi TSUTSUI, Hiroshi Tokado, K Noda, Sadao NAKANE, Michitada SASAJIMA, Masahiro OHZEKI
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    TLDR Hydrocortisone 17-butyrate 21-propionate ointment caused reversible side effects like skin issues, weight gain, and organ changes in dogs.
    The study investigated the subacute toxicity of 0.1% and 0.5% hydrocortisone 17-butyrate 21-propionate (HBP) ointment in beagle dogs over 3 months. Results showed acne-like changes and inhibited hair growth at application sites, increased body weight, food and water consumption, and obesity in the 0.5% ointment groups. Hematological and biochemical changes included decreased lymphocytes and eosinophils, increased cholesterol, triglycerides, urine volume, and potassium. Autopsies revealed thymus and adrenal weight loss, gastric mucosa hemorrhage, and histopathological findings of atrophy in various tissues and hepatocyte enlargement. These effects were reversible after a 1-month recovery at lower doses. HBP and HB exhibited similar toxicity, slightly less than BV.
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