Topical Retinoids: Role and Place in Acne Therapy

Topical retinoids, derivatives of vitamin A, have been effectively used in acne treatment for over 50 years due to their impact on cell differentiation, proliferation, and apoptosis. They are particularly effective for comedonal acne and, when combined with antimicrobials like clindamycin, for mild to moderate papulopustular acne. The study emphasizes the efficacy and safety of adapalene 0.1% gel and its combinations, such as "Deriva," "Deriva C," and "Deriva C MS," highlighting their rapid action and good patient adherence.