Successful Use of Topical Minoxidil in the Treatment of Hypotrichosis Associated with Desmoplakin Mutations
August 2019
in “
Pediatric dermatology
”
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Studysummary This study reports that topical minoxidil 5% foam may effectively promote hair growth in congenital alopecia and hypotrichosis linked to desmoplakin mutations, as demonstrated by significant hair growth in an 8-year-old boy.
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An 8-year-old boy with congenital alopecia and long-standing hypotrichosis due to two heterozygous mutations in the DSP gene encoding desmoplakin was treated with off-label topical minoxidil 5% foam once daily. After 2 months, he experienced dramatic hair growth, and the results were sustained at 1 year. This case suggested that topical minoxidil could be effective in managing hair abnormalities associated with desmoplakin mutations.
