Experience with Tofacitinib and Baricitinib in Rheumatoid Arthritis

    March 2020 in “ Section 5: Patient safety and quality assurance ”
    MI Bernias Domínguez, M Mañes Sevilla, PM Bernias Domínguez, L Corrales Pérez, Isabel Sancho, I Morona Mínguez, J Solis Olivares, Carolina Sánchez
    Image of study
    TLDR Tofacitinib and baricitinib had an acceptable level of side effects in rheumatoid arthritis patients.
    In a retrospective observational study conducted until September 2019, 47 patients with rheumatoid arthritis (RA) were analyzed for adverse effects (AEs) following treatment with tofacitinib and baricitinib at a second level hospital. The study included 12.8% men with a mean age of 57 years. All patients had previously been treated with disease-modifying antirheumatic drugs (DMARDs), and 55.3% had received biologic agents, with an average of 1.7 previous biological treatments. A total of 24 AEs were detected in 31.9% of patients, with 30.8% of those on baricitinib and 28.6% on tofacitinib experiencing AEs such as infections, fatigue, changes in blood pressure, and hair loss. Baricitinib was discontinued in six cases due to lack of clinical improvement or AEs, while tofacitinib was stopped in five cases due to inefficacy or AEs. Despite potential underreporting of AEs, both drugs demonstrated an acceptable adverse reaction profile, consistent with their technical data sheets.
    Discuss this study in the Community →

    Related Community Posts Join

    5 / 5 results

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       8 upvotes 8 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

      community No hair, don't care! [24/F] :)

       61 upvotes 8 years ago
      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

    Similar Research

    5 / 683 results