TNF-Alpha in Nonscarring Inflammatory Alopecia

March 2014 in “ Journal of The American Academy of Dermatology ”

TNF-a nonscarring inflammatory alopecia alopecia areata telogen effluvium cytokine androgenetic alopecia outer root sheath TNF-a inhibitors TNF-alpha AA TE AGA

TLDR TNF-a may not be as involved in certain types of hair loss as previously thought.

The document presents findings from a study examining the role of TNF-a in nonscarring inflammatory alopecia, specifically alopecia areata (AA) and telogen effluvium (TE). The study hypothesized that TNF-a levels would be increased in biopsies from AA and TE due to the cytokine's involvement in the pathogenesis of these conditions and its correlation with stress, a known precipitating factor for these types of hair loss. Scalp biopsies from cases of AA, TE, androgenetic alopecia, and control samples from benign nevi excisions were stained for TNF-a and evaluated. Contrary to the hypothesis, the results showed that controls had the highest rate of positive TNF-a staining, while AA and TE had significantly less staining of the outer root sheath. These findings suggest that TNF-a may not play the expected role in AA and TE and could explain cases where patients developed AA while taking TNF-a inhibitors. No commercial support was identified for this study.

View this study on doi.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 7 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 3 months. Dut, Min, Keto, Vitamin D, exercise

in Progress Pictures 353 upvotes 2 years ago

A user's experience using dutasteride, minoxidil, ketoconazole, vitamin D, scalp massage, exercise, and avoiding vaping and 2-in-1 shampoo/conditioner to treat hair loss; they also discussed the side effects of finasteride.

community Topical Finasteride update by H&W

in Finasteride 28 upvotes 7 years ago

The conversation discusses using topical finasteride for hair loss, with concerns about its safety around family members, especially pregnant women and infants. One user plans to try topical finasteride due to side effects from the pill.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 444 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

Similar Research

5 / 1000+ results

research Therapies for Onychomycosis: A Systematic Review and Network Meta-Analysis of Mycologic Cure

March 2014 in “Journal of The American Academy of Dermatology”

Terbinafine 250 mg is the most effective treatment for fungal nail infections.

research Histopathology of Scarring and Nonscarring Hair Loss

17 citations, September 2012 in “Dermatologic Clinics”

The conclusion is that accurate diagnosis of different types of hair loss requires careful examination of tissue samples and understanding of clinical symptoms.

research Topical Botanical Extract for Management of Chemotherapy-Induced Alopecia

March 2014 in “Journal of The American Academy of Dermatology”

A botanical extract may help manage hair loss from chemotherapy by preventing cell death in hair follicles.

research The Impact of Hair Care Practices and Attitudes Toward Hair Management on Exercise Habits in African American Women

1 citations, March 2014 in “Journal of The American Academy of Dermatology”

Hair care practices and concerns about maintaining hairstyles can reduce how often African American women exercise.

research Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review

21 citations, June 2019 in “Dermatologic Surgery”

Platelet-rich plasma (PRP) treatment has been found effective in promoting hair growth for alopecia patients, with minimal side effects like temporary pain and redness.