Tick Bites: The View from Inside-Out

    January 2009 in “ Nova Science Publishers (Nova Science Publishers, Inc.) ”
    Elena Castelli, Rosa Maria Tomasino, Vincenza Morello
    TLDR Tick bites cause skin damage and long-lasting reactions.
    The study examined the tick feeding process in humans, focusing on the local effects on skin lesions and tick samples. It was found that the tick's mouthparts were embedded in a cement cone, with the pharynx equipped with anti-reflux valves and dilating muscles. The surrounding dermis was altered, showing a network of fibrin, endothelia, and collagen fibers, along with edema, blood, and a dense neutrophilic infiltrate. Blood vessels exhibited interruptions, blood extravasation, endothelial proliferation, and vasculitis. Post-tick removal, skin reactions such as Erythema Chronicum Migrans-like patches, foreign body granuloma, T- and B-cell lymphoid hyperplasia, and alopecia areata-like hair loss were observed.
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