Analysis of Thymosin β4 and Vascular Endothelial Growth Factor Expression in Normal Human Tissues Using Tissue Microarray

The study investigated the expression patterns of Thymosin β4 and VEGF in various normal human tissues using tissue microarray analysis. Thymosin β4 was highly expressed in the liver, pancreas, ductal epithelium of the salivary gland, and heart, and moderately expressed in the skin, lung, spleen, lymph node, thymus, ureter, and blood endothelial cells in the lung and adrenal gland. VEGF expression generally co-localized with Thymosin β4 and was highly expressed in the pancreas, ureter, mammary gland, liver, esophagus, and blood endothelial cells in the lung and adrenal gland. The results suggested that Thymosin β4 plays an important role in various organs and may induce or maintain angiogenesis, similar to VEGF.