Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

The document reviewed advancements in the development of neural organoids and their potential applications in treating central nervous system (CNS) diseases. It categorized research into three approaches: direct organization of region-specific neural organoids, assembly of organ-specific progenitor or stem cells, and induction of multilayer organoids from embryoid bodies. While significant progress was made in understanding brain organogenesis, most studies focused on cellular and molecular mechanisms rather than direct disease treatment. The review analyzed these approaches' potential future implications for CNS disease treatment based on their unique characteristics.