Studysummary In this study, ozone treatment was shown to increase the concentration of growth factors like EGF and TGF-β in PRP in vitro, suggesting that oxygen-rich PRP injections may provide an effective method for facial rejuvenation. Our plain-language summary of this paper — not a Tressless recommendation.
This study on 26 patients assessed the effects of oxygen-rich PRP injections for facial rejuvenation. Results showed that high-dose ozonized PRP increased growth factors like EGF and TGF-β, enhancing tissue repair and collagen thickness by up to 30% in the forehead, cheek, and neck, with effects lasting up to 6 months. Skin conditions such as spots and texture improved significantly, though wrinkles and pore size did not. Patient satisfaction was high, with 46.2% reporting significant improvement and 53.85% willing to repeat the treatment. The procedure was well-tolerated, with a median pain score of 4.19 out of 10, and minor side effects like edema and redness resolved quickly. The study suggests that oxygen-rich PRP injections, especially with ozone activation, are promising for facial rejuvenation, but further research is needed on activation methods and pain management.
18 citations
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March 2022 in “Drug design, development and therapy” This review examines the definition, classification, mechanism, clinical efficacy for hair regrowth, and potential adverse effects of platelet rich plasma, but does not present new experimental results.
3 citations
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November 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review evaluated existing studies on platelet-rich plasma for facial rejuvenation and found limited clinical evidence supporting its effectiveness, suggesting that more research is needed to establish its utility.
76 citations
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February 2021 in “International Journal of Molecular Sciences” This review examines how mesenchymal stem cells and their derivatives may enhance skin regeneration and rejuvenation, but it reports no new clinical results; the authors suggest iPSC-derived MSCs hold promise for future therapies.
848 citations
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October 2020 in “International Journal of Molecular Sciences” This review discusses the potential of platelet-rich plasma applications in regenerative medicine and explores recent progress and challenges in translating non-clinical PRP findings into human treatments, but reports no new clinical results.
1160 citations
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November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
348 citations
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July 2017 in “Skin appendage disorders” This review discusses the use of platelet-rich plasma in dermatology for various applications such as tissue regeneration and wound healing, but it reports no new clinical results and calls for clearer guidance on suitable treatments.
