TLDR Recognizing specific tissue types on telogen hair roots can improve DNA typing.
The study focused on characterizing the tissues attached to telogen hair roots using transmission and scanning electron microscopy, as these hairs are often submitted for DNA typing in forensic laboratories. The research identified that the tissues consisted of keratinized remnant follicle, nonnucleated epithelial cells, nucleated epithelial cells, and trichilemmal keratin. These findings aligned with the principles of hair follicle regression. The study suggested that recognizing these specific tissue types could improve DNA typing of telogen hairs, emphasizing that the quality of tissue might be more crucial than the quantity for successful DNA analysis.
138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” The document reviewed the genomic organization and expression characteristics of human hair keratin genes, highlighting their role in hair follicle biology and hereditary disorders. It noted that research on human hair keratins lagged behind studies in other species. The review discussed the complex regulatory mechanisms of hair keratin expression and the differentiation of hair follicle compartments. It also addressed keratin-related pathologies, such as epidermolysis bullosa simplex and pachyonychia congenita, which affect the outer root sheath and nail beds, respectively. The study emphasized the need for further research to understand the molecular mechanisms governing hair follicle differentiation and keratin expression.
23 citations
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February 2004 in “British Journal of Dermatology” Keratin in mouse hair follicles is complex and plays specific roles.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
10 citations
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October 2000 in “PubMed” 
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
135 citations
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November 1987 in “Differentiation”
