The proteomics of keratin proteins

    August 2006 in “ Journal of Chromatography B ”
    Jeffrey E. Plowman
    TLDR Modern techniques have improved the understanding of keratin proteins, revealing their roles in various cells and potential in disease diagnosis.
    Keratin proteins, known for their structural role in hair, wool, and skin, were challenging to study due to extraction difficulties, high sequence homology, and post-translational modifications. However, modern proteomic techniques, such as mass spectrometry, improved the analysis of these proteins. Keratins were found in various cell types, including epithelial, neuronal, and glial cells, and were involved in forming intermediate filaments. The study of keratins extended beyond hair and wool to other tissues, recognizing their role in diseases and potential for diagnostic tool development. Despite the challenges, advancements in proteomics provided valuable insights into the complex nature of keratin proteins.
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