The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

The study investigated the neuropharmacological effects of methanolic extract of Crataeva nurvala leaves (MECN) on male Swiss albino mice, focusing on its sedative and anxiolytic properties. MECN was administered at doses of 50, 100, and 200 mg/kg body weight, and its effects were evaluated using various behavioral tests. The results indicated that MECN exhibited dose-dependent sedative effects by inhibiting locomotor activities and motor coordination. It also showed significant anxiolytic effects, as evidenced by behavioral changes in tests like the elevated plus maze and light-dark box. The study suggested that these effects might be mediated through the GABAergic system, as MECN potentiated thiopental sodium-induced hypnosis. Phytochemical analysis identified 48 compounds in MECN, with neuroactive compounds such as phytol, D-allose, and α-Tocopherol potentially contributing to its effects. The findings suggested that MECN could be beneficial for treating anxiety and insomnia related to psychological disorders.