The Influence of the MDR1 C3435T Polymorphism on Methotrexate Responsiveness in Rheumatoid Arthritis Patients

July 2020 in “ The Egyptian Journal of Hospital Medicine ”

Shahira Fathy El Fedawy, Abeer Shehab, Rania A. Abo‐Shady, Samah A. El-Bakry, Dina Ragab, Sara Salem, Nermeen Samy

methotrexate MDR1 C3435T polymorphism hair loss

TLDR The MDR1 C3435T polymorphism does not significantly affect methotrexate response in rheumatoid arthritis patients.

This study investigated the influence of the MDR1 C3435T polymorphism on methotrexate responsiveness in 90 rheumatoid arthritis patients, predominantly female (88.9%). Patients were categorized into methotrexate responders and non-responders based on their disease activity score (DAS28). The study found no statistically significant difference in genotype or allele frequencies between the two groups. However, patients with the C allele were 1.65 times more likely to be non-responders compared to those with the T allele. Common methotrexate adverse effects included gastrointestinal upset (31.1%) and hair loss (11.1%). The study concluded that there was no significant association between the MDR1 C3435T polymorphism and methotrexate responsiveness in these patients.

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