The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim
July 1990
in “British Journal of Pharmacology”
TLDR Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.
The study compared the effects of diazoxide, minoxidil sulphate, and cromakalim on rat blood vessels. All three agents exhibited K+ channel opening properties in vascular smooth muscle, leading to hyperpolarization and relaxation of the vessels. Diazoxide had an additional inhibitory action not related to the production of cyclic AMP or cyclic GMP. Minoxidil sulphate had a smaller effect on 86Rb efflux and may primarily act on a K+ channel that is relatively impermeable to 86Rb. The study provides insight into the mechanisms of action of these antihypertensive agents on blood vessels.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.
The study explains how minoxidil sulfate causes vasodilation in rabbits by opening potassium channels and inhibiting calcium channels.
research Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.
research Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.
Minoxidil sulfate relaxes muscle by increasing potassium flow, making it a unique muscle relaxer.
research Sulfation of minoxidil by liver sulfotransferase
Liver enzyme helps minoxidil work better for blood vessel relaxation.
Related
research The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim
Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.