Sweet Syndrome: An Unusual Presentation of Chronic Granulomatous Disease in a Child
June 1999
in “
The Pediatric Infectious Disease Journal
”
Studysummary In this case report, a 2-year-old boy initially diagnosed with Sweet syndrome was later found to have chronic granulomatous disease, highlighting the importance of considering CGD in unusual cases of Sweet syndrome.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report described a 2-year-old African-American male who initially presented with Sweet syndrome, characterized by fever, neutrophilic leukocytosis, and painful skin plaques, but was later diagnosed with chronic granulomatous disease (CGD), a rare inherited disorder affecting phagocytic cell function. The diagnosis of CGD was complicated by unusual test results and the presence of granulomas, which are atypical for Sweet syndrome. Despite initial treatment challenges, the patient responded to increased prednisone and dapsone, leading to symptom improvement and no relapse. This case highlighted the variable presentation of CGD and the need for high clinical suspicion when Sweet syndrome presents with granulomas and a slow steroid response.
