Sweet Syndrome: An Unusual Presentation of Chronic Granulomatous Disease in a Child

This case report described a 2-year-old African-American male who initially presented with Sweet syndrome, characterized by fever, neutrophilic leukocytosis, and painful skin plaques, but was later diagnosed with chronic granulomatous disease (CGD), a rare inherited disorder affecting phagocytic cell function. The diagnosis of CGD was complicated by unusual test results and the presence of granulomas, which are atypical for Sweet syndrome. Despite initial treatment challenges, the patient responded to increased prednisone and dapsone, leading to symptom improvement and no relapse. This case highlighted the variable presentation of CGD and the need for high clinical suspicion when Sweet syndrome presents with granulomas and a slow steroid response.