Is Spontaneous Regrowth in Alopecia Areata Possible: A Systematic Review and Meta-Analysis of Placebo-Controlled Studies

    October 2025 in “ Acta Dermato Venereologica ”
    Beata Jastrząb-Miśkiewicz, Jacek C. Szepietowski, David Saceda Corralo, Piotr K. Krajewski
    TLDR Spontaneous hair regrowth in alopecia areata is possible but varies greatly among individuals.
    The systematic review and meta-analysis conducted by Jastrząb-Miśkiewicz et al. investigates the possibility of spontaneous regrowth in alopecia areata through an analysis of placebo-controlled studies. The study highlights that spontaneous hair regrowth is indeed possible in cases of alopecia areata, although the likelihood and extent of regrowth can vary significantly among individuals. The analysis included a comprehensive review of existing literature and data, providing a robust examination of the phenomenon. The findings suggest that while spontaneous regrowth can occur, it is not guaranteed, and the variability in outcomes underscores the need for further research to better understand the underlying mechanisms and potential predictors of regrowth in alopecia areata patients.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Diffuse thinning is so brutal.

      in Styling  72 upvotes 2 years ago
      A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

      community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

      in Treatment  8 upvotes 5 years ago
      Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

      community Unofficial Dermapen/Roller Guide

      in Treatment  256 upvotes 7 years ago
      Treatments for hair loss, including microneedling (dermarolling and dermapen) and the use of minoxidil, finasteride, and RU58841. It provides detailed information about cost and usage of the various treatments, as well as potential side effects.

      community A PSA for everyone in here dealing with shedding

      in Treatment  72 upvotes 1 year ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride require patience, as they can take months or years to show results, with initial shedding being common. Consistency is key, and unnecessary supplements should be avoided to prevent stress and impatience from worsening the situation.

      community Pattern hair loss could be due to gut bacteria

       51 upvotes 6 years ago
      Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.

    Similar Research

    5 / 1000+ results