Solid State NMR of Isotope Labeled Murine Fur: A Powerful Tool to Study Atomic Level Keratin Structure and Treatment Effects

    October 2016 in “ Journal of Biomolecular NMR ”
    Wai Ching Wong, Aurimas Narkevicius, Wing Ying Chow, David G. Reid, Rakesh Rajan, Roger A. Brooks, Maggie Green, Melinda J. Duer
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    The study used solid-state NMR with isotope-labeled murine fur to explore keratin structure at an atomic level, achieving enhanced resolution through 2D NMR methods. This allowed for detailed observation of amino acid residues, such as Gly, Ser, and Thr, which was not possible with 1D experiments. The research demonstrated the potential of this method to study chemical and structural changes in keratin due to treatments, despite some limitations due to overlapping signals from critical residues.
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