Systemic Lupus Erythematosus in a Patient with Psoriasis During PUVA Treatment

    January 1979 in “ Archives of Dermatology ”
    Steven Eyanson
    TLDR PUVA treatment may have triggered lupus in a woman with psoriasis.
    A 23-year-old woman with psoriasis developed systemic lupus erythematosus (SLE) during treatment with psoralen-ultraviolet-A (PUVA). Her condition was marked by symptoms such as an erythematous rash, hair loss, nephritis, splenomegaly, seizures, and coma. High titers of serum antinuclear antibodies and hypocomplementemia were observed, although antibodies to native or ultraviolet-irradiated DNA were not found. The study suggested that the PUVA treatment might have played a role in the onset of SLE, although the link between psoriasis and lupus could have been coincidental.
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