Usefulness and Limitations of the Evaluation of Sex-Hormone-Binding Globulin in Women With Androgen-Induced Baldness

September 1989 in “ PubMed ”

Giuseppe Noto, F Maneschi, F Palisi, G Pravatà, Maurizio Aricò

sex-hormone binding globulin androgen female pattern androgenetic alopecia androgenetic alopecia hyperandrogenism SHBG AA

TLDR Genetic response to androgens is key in female pattern baldness, not SHBG levels.

The study evaluated sex-hormone binding globulin (SHBG) and androgen serum levels in women with stage II female pattern androgenetic alopecia (AA) who did not exhibit clinical signs of acne, hirsutism, or irregular menses. Results showed no significant differences in SHBG levels between patients and controls. The study suggested that previous inconsistent findings might be due to varying levels of "cryptic" hyperandrogenism in different study populations. The researchers concluded that the genetically-determined response of target organs to androgens played a significant role in AA, especially in the absence of evident hyperandrogenism.

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research Bioactive and Peripheral Androgens in Prepubertal Simple Hypertrichosis

11 citations , September 1990 in “Clinical Endocrinology”

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