The Hair Loss Encyclopedia

Case Report: Disorder of Sexual Development in a Chinese Crested Dog With XX/XY Leukocyte Chimerism and Mixed Cell Testicular Tumors

July 2022 in “ Frontiers in Veterinary Science ”

Rebecca M. Schwartz, Nicole Sugai, Kristin Eden, Caitlin Castaneda, Matthew Jevit, Terje Raudsepp, Julie T. Cecere

Anti-Mullerian Hormone Sertoli cell hyperplasia Leydig cell tumors gonadectomy chimerism chromosomal sex

TLDR A female dog with mixed male and female traits was treated successfully with surgery.

This case report described a 10-year-old female Chinese Crested dog with a disorder of sexual development due to XX/XY leukocyte chimerism and mixed cell testicular tumors. Despite having normal female external genitalia, the dog had male gonadal tissue, confirmed by a positive Anti-Mullerian Hormone test. Histopathology showed Sertoli cell hyperplasia and Leydig cell tumors, while cytogenetic analysis revealed a chimeric pattern in blood leukocytes. The disorder was attributed to a blood chimera with mixed chromosomal sex. The feminizing symptoms caused by hormonally active Sertoli cell tumors were resolved after gonadectomy, highlighting the importance of genetic evaluation and surgical intervention in such cases.

View this study on frontiersin.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community I wish we didn’t have to live with this….

61 upvotes 6 years ago

The struggles of hair loss at a young age and available treatments, such as medication (Finasteride, Minoxidil, Dutasteride, Derma Rolling) and potential options for hair systems or cloning in Japan. People discussed their own experiences with trying to cope with the emotional aspects of this condition.

community Is hair thinning or loss associated with pain?

in Research/Science 6 upvotes 2 years ago

Hair thinning/loss associated with burning scalp pain. Finasteride helped relieve "DHT itch" for one person.

community 9 months on Finasteride 1,25mg + HRT

in Transgender 17 upvotes 1 year ago

The conversation is about the results of using hormone replacement therapy (HRT) with estrogen and finasteride for hair loss, and switching from finasteride to bicalutamide as an anti-androgen treatment. The user shared before and after photos to discuss the effectiveness of these treatments.

community Does anyone know where do buy Fluridil?

in Research/Science 3 upvotes 2 years ago

User seeks Fluridil for hair loss treatment and asks for reliable sources to purchase it. MinoxidilMax and eucapil-shop.com mentioned as potential options.

community [M29] Finasteride + Minoxidil + Microneedling results

in Progress Pictures 217 upvotes 4 years ago

User reports hair loss improvement using finasteride, minoxidil, and microneedling. Others praise progress and share experiences.

community Pyrilutamide available at Actifolic now

in Research/Science 15 upvotes 3 years ago

Pyrilutamide, a new hair loss product with the potential to be more effective than RU58841 and safer than CB, but expensive.

Similar Research

5 / 1000+ results

Genetic Defects of Female Sexual Differentiation

research Genetic Defects of Female Sexual Differentiation

November 2016 in “Elsevier eBooks”

Genetic mutations can affect female sexual development, requiring personalized medical care.

New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men

research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men

14 citations , January 2018 in “Advances in Clinical Chemistry”

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations , March 2016 in “Urologic Clinics of North America”

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

research Androgen Treatment in Adolescent Males With Hypogonadism

19 citations , May 2020 in “American journal of men's health”

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

Modeling Androgen Synthesis and Action During Human Sexual Differentiation

research Modeling Androgen Synthesis and Action During Human Sexual Differentiation

February 2010 in “ePrints Soton (University of Southampton)”

Male sexual differentiation is regulated independently, while female differentiation occurs in an androgenic environment, affecting conditions like congenital adrenal hyperplasia.