The Effects of Sex Hormones and Some Respiratory Diseases on the Severity of Coronavirus Infection

This study investigated the impact of sex hormones and chronic respiratory diseases on Covid-19 severity and mortality, involving 85 patients with bronchial asthma or lung cancer. It found that males, particularly those with asthma, had a higher death rate (18%), with 70% of deceased males having asthma. Postmenopausal women also had a high death rate (66.7%), while pre-menopausal women had a 100% cure rate, linked to higher progesterone levels (13.55 ng/ml) which were associated with moderate symptoms. Conversely, increased testosterone levels in males and postmenopausal women were linked to more severe infections. Asthma and high testosterone were associated with increased Covid-19 severity and mortality, whereas progesterone appeared protective in young women.