Evaluation of Serum Level of Human Beta Defensin 1 in Patients With Alopecia Areata

October 2022 in “ Benha Journal of Applied Sciences ”

A.A. Abd El-moneam, A.A. Ebrahim, A.I. Mustafa, W.A. Abd-Halim

human beta defensin 1 alopecia areata autoimmune disease non-scarring hair loss HBD-1 AA

TLDR Human Beta Defensin 1 levels do not predict the risk or severity of Alopecia Areata.

The study "Evaluation of serum Level of Human Beta Defensin 1 patients With Alopecia Areata" conducted by A.A. Ebrahim, A.I. Mustafa, and W.A. Abd-Halim from the Dermatology Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt, aimed to understand the role of human beta defensin 1 (HBD-1) in the pathogenesis of alopecia areata (AA), an autoimmune disease causing non-scarring hair loss. The prospective case-control study involved 40 patients with AA and 40 age and sex-matched healthy subjects. The results showed no significant difference in serum levels of HBD-1 between the AA group and the control group (p=0.03). The study concluded that HBD-1 concentration is not a predictor of AA susceptibility and severity.

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