Evaluation of Serum Level of Human Beta Defensin 1 in Patients With Alopecia Areata

October 2022 in “ Benha Journal of Applied Sciences ”

A.A. Abd El-moneam, A.A. Ebrahim, A.I. Mustafa, W.A. Abd-Halim

human beta defensin 1 alopecia areata autoimmune disease non-scarring hair loss HBD-1 AA

TLDR Human Beta Defensin 1 levels do not predict the risk or severity of Alopecia Areata.

The study "Evaluation of serum Level of Human Beta Defensin 1 patients With Alopecia Areata" conducted by A.A. Ebrahim, A.I. Mustafa, and W.A. Abd-Halim from the Dermatology Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt, aimed to understand the role of human beta defensin 1 (HBD-1) in the pathogenesis of alopecia areata (AA), an autoimmune disease causing non-scarring hair loss. The prospective case-control study involved 40 patients with AA and 40 age and sex-matched healthy subjects. The results showed no significant difference in serum levels of HBD-1 between the AA group and the control group (p=0.03). The study concluded that HBD-1 concentration is not a predictor of AA susceptibility and severity.

View this study on bjas.journals.ekb.eg →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 1 year ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 8 months ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Holy shit. Verteporfin may actually be the cure

in Research/Science 1012 upvotes 1 year ago

The post and conversation discuss Verteporfin's potential as a hair loss treatment. It's shown promise in regrowing hair after transplants and might be effective with microneedling.

community Phase II Clinical Trial for TDM-105795 started recruiting

in Research/Science 23 upvotes 2 years ago

A Phase II clinical trial for TDM-105795 has started recruiting in the US, and it might be a promising treatment for hair loss. Many hair loss drugs, including this one, originate from China.

community Progress - 1mg Oral Fin daily, 11 months

in Progress Pictures 152 upvotes 2 months ago

The user experienced positive hair regrowth using 1mg oral finasteride daily, Nizoral 2% shampoo every three days, and dermastamping, without adding minoxidil due to satisfaction with current results. Initial side effects like erectile dysfunction and dry eyes resolved over time.

Related Research

3 / 3 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.

research Oral Tofacitinib: A Promising Treatment in Atopic Dermatitis, Alopecia Areata, and Vitiligo

37 citations, October 2017 in “Clinical and Experimental Dermatology”

Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.

research Vitiligo After Diphencyprone for Alopecia Areata

18 citations, January 2010 in “Dermatology Research and Practice”

DPCP treatment for alopecia areata can sometimes cause vitiligo.