Self Prion Protein Peptides Are Immunogenic in Lewis Rats

December 2001 in “ Journal of autoimmunity ”

Lina Souan, Raanan Margalit, Ori Brenner, Irun R. Cohen, Felix Mor

prion protein peptides MHC class II RT1.B1 motif immune response skin inflammation hair loss

TLDR Rats can develop an immune response to prion protein peptides, but it may cause severe skin issues in older rats.

The study investigated the immunogenicity of prion protein peptides in Lewis rats by immunizing them with peptides fitting the MHC class II RT1.B1 motif. Both humoral and cellular immune responses were observed without adverse effects in young rats. However, in 8-month-old rats, 6 out of 36 developed severe skin inflammation and hair loss. These results indicated that self-prion peptides could induce an immune response in Lewis rats, potentially leading to pathogenic outcomes in older animals.

View this study on sciencedirect.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 585 results

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community Obviously, all of us who are serious take antiandrogens and growth stimulants - what else are you doing lifestyle wise, dietary wise, and regiment wise to maximize your results?

in Treatment 21 upvotes 5 months ago

The user follows a hair loss treatment routine including Propecia, oral minoxidil, ketoconazole, and plans to switch to dutasteride. They also focus on lifestyle changes, dietary supplements, and are considering laser therapy.

community 6 months progress no fin 27m topical foam minox

in Progress Pictures 250 upvotes 1 year ago

The user has been using 5% Minoxidil foam twice daily, microneedling every two weeks, and Nizoral 2% shampoo weekly for hair loss treatment. They've seen improvements in their hairline and eyelashes, and are considering adding finasteride to their regimen.

community Finasteride 4 months way worse then when I started, shed or am I cooked? 19m

in Progress Pictures 169 upvotes 3 months ago

A 19-year-old experienced worsening hair loss after 4 months on finasteride, despite initial improvement with minoxidil. The consensus is to continue treatment for at least a year, as shedding is common and often temporary.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Testosterone is 1600, would taking low dose anti-androgens be a viable treatment option for people who’s T spikes on DHT-blockers?

in Treatment 45 upvotes 1 year ago

The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.

Similar Research

5 / 1000+ results

research Analysis of Protein Interactions by Surface Plasmon Resonance

42 citations, September 2017 in “Advances in protein chemistry and structural biology”

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

research Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations, July 2023 in “Biomolecules”

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

research Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-Versus-Host Disease

47 citations, June 2013 in “Biology of blood and marrow transplantation”

Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.

research The Function and Structure of the Skin

4 citations, November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

Alopecia Areata Susceptibility Variant Identified by MHC Risk Haplotype Sequencing Reproduces Symptomatic Patched Hair Loss in Mice

research Alopecia Areata Susceptibility Variant Identified by MHC Risk Haplotype Sequencing Reproduces Symptomatic Patched Hair Loss in Mice

April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

A gene variant causes patched hair loss in mice, similar to alopecia areata in humans.