Self-Assembled Peptide Hydrogels in Regenerative Medicine

The document discusses the use of self-assembled peptide hydrogels in regenerative medicine, particularly in skin, bone, and neural healing. These hydrogels mimic the cytoplasmic matrix environment, promoting cell adhesion, migration, proliferation, and division. Self-assembled short peptide (SASP) hydrogels have been used in skin regeneration, tissue engineering, drug release, hemostasis, and antimicrobial action. SASP hydrogels have also shown potential in bone regeneration, enhancing key osteogenic markers. In nerve regeneration, they enhance the adhesion of neural stem cells and their differentiation into neuronal cells. However, they have limitations including poor stability, biocompatibility, and mechanical properties. The document also highlights the potential of these hydrogels in treating neurological disorders and injuries, promoting neural growth after peripheral nerve injury. Despite promising results, further studies are needed to optimize these peptides for broader applications in tissue engineering.