TLDR Selenoproteins are crucial for healthy skin and hair.
This study demonstrated that selenoproteins were crucial for proper skin and hair development, as well as keratinocyte function. Researchers generated mice lacking selenoproteins in keratin 14 expressing cells, which resulted in skin abnormalities, hyperplastic epidermis, aberrant hair follicle morphogenesis, and progressive alopecia. These mice also exhibited a runt phenotype and premature death. The findings highlighted the essential role of selenoproteins as antioxidants in the skin and their importance in keratinocyte growth and viability. The study provided genetic evidence linking severe selenoprotein deficiency to skin and hair abnormalities.
1398 citations
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May 2008 in “Histochemistry and Cell Biology” Keratins are crucial for cell stability, wound healing, and cancer diagnosis.
106 citations
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June 2005 in “Journal of Investigative Dermatology” The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.
April 2024 in “Cell death and differentiation” Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.
79 citations
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January 2017 in “Dermatology practical & conceptual” Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.
1 citations
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September 2013 in “Elsevier eBooks” Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.
41 citations
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June 2006 in “Journal of Investigative Dermatology” Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.
20 citations
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June 2010 in “Genes and Immunity” Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.
