Segmental Hair Analysis for 11-Nor-9-Tetrahydrocannabinol-9-Carboxylic Acid and the Patterns of Cannabis Use

March 2012 in “ Journal of Analytical Toxicology ”

Eui‐Ryoung Han, Heesun Chung, Jinzhu Song

11-nor-9-carboxy-Δ9-tetrahydrocannabinol THCCOOH segmental hair analysis gas chromatography–tandem mass spectrometry THC-COOH GC-MS

TLDR THCCOOH levels in hair decrease from root to tip and don't match well with self-reported cannabis use.

This study aimed to detect 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) in segmental hair to evaluate cannabis use patterns. Hair samples were processed and analyzed using gas chromatography–tandem mass spectrometry. Results showed that THCCOOH concentrations decreased from the proximal to distal hair segments. There was a poor correlation between THCCOOH levels in hair and self-reported cannabis use due to the low accuracy of self-reported data. Despite this, the study provided preliminary insights into the dose and frequency of cannabis use among users in the country.

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