Combination of Secukinumab and Acitretin for Generalized Pustular Psoriasis: A Case Report and Review of Literature
April 2024
in “
Journal of International Medical Research
”
Studysummary This case report describes a female patient with ankylosing spondylitis who developed generalized pustular psoriasis after adalimumab therapy, and whose condition improved following treatment with secukinumab and acitretin.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report describes a 49-year-old woman with ankylosing spondylitis and mild scalp psoriasis who developed generalized pustular psoriasis and alopecia after adalimumab therapy. Her condition improved significantly with a combination of secukinumab and acitretin, achieving almost complete clearance of psoriasis and improvement in alopecia and AS symptoms within 8 weeks. The report suggests that this combination therapy may be an effective and rapid treatment option for severe GPP, especially when induced by TNF-α inhibitors like adalimumab, with minimal adverse effects. However, the authors highlight the need for larger, randomized controlled studies to confirm these findings.
