The Analysis of Scalp Irritation by Coacervates Produced in Hair Shampoo via FTIR with Focal Plane Array Detector, X-ray Photoelectron Microscopy and HaCaT Cells

The study aimed to analyze coacervates formed by hair shampoos to identify components responsible for scalp irritation. Using FTIR-FPA and XPS, the researchers found that coacervates are macromolecules similar to cationic polymers containing anionic surfactants. These surfactants are semi-stable and release onto the scalp when exposed to moisture, leading to potential scalp irritation. HaCaT cells were used to test the irritant properties of the coacervates, confirming that the release of sulphate bonding into the matrix upon water exposure could cause scalp stimulation.