Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

This review highlights the transformative potential of scaffold-based drug delivery systems in oral cancer treatment, emphasizing their ability to enhance therapeutic outcomes through targeted and localized drug administration. Scaffolds coated with anti-cancer agents like cisplatin and paclitaxel effectively inhibit cancer cell proliferation and offer site-specific drug delivery. The use of synthetic and natural materials in 3D systems allows for controlled release of therapeutic agents, minimizing systemic side effects such as nausea and alopecia. Smart scaffolds designed for sequential therapy and combinatorial approaches promise precise interventions and improved patient outcomes. Despite challenges like fabrication complexity and biocompatibility, the outlook for scaffold-based systems in oral cancer therapy is optimistic, with ongoing advancements aiming to overcome current limitations.