Scabicidal Potential of Coconut Seed Extract in Rabbits via Downregulating Inflammatory/Immune Cross-Talk: A Comprehensive Phytochemical/GC-MS and In Silico Proof
December 2022
in “Antibiotics”
TLDR Coconut seed extract may effectively treat scabies in rabbits by killing mites and reducing inflammation.
The study investigated the potential of coconut seed extract (CSE) as a treatment for scabies in rabbits. The extract, containing 17 known compounds, improved all signs of infection when applied topically, with improvements starting 3 days post application. In vitro application resulted in 99% mite mortality 1 day post application. The extract suppressed certain inflammatory markers and upregulated others, suggesting its potential as an efficient, cost-effective, herbal-based alternative for scabies control. The study also demonstrated CSE's high affinity towards proteins involved in the mite's life cycle, particularly gondoic acid and a sugar compound. The fatty acids in CSE contributed to the fast recovery of the rabbits, reducing inflammation and promoting collagen formation for wound healing. The study involved 20 rabbits divided into 4 groups of 5.
View this study on mdpi.com →
Cited in this study
research Mange in Rabbits: An Ectoparasitic Disease with Zoonotic Potential
Mange in rabbits is a serious disease that can spread to humans and is treated with medications and supportive care.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
Related
research Prevalence and Severity of Scabies (Sarcoptes Scabiei) on Rabbits in Kuala Lumpur City
Scabies affects 9.29% of rabbits in Kuala Lumpur, mostly with mild symptoms.