SARS-CoV-2 Non-Structural Proteins and Their Roles in Host Immune Evasion

    September 2022 in “ Viruses ”
    Zheng Yao Low, Nur Zawanah Zabidi, Ashley Jia Wen Yip, Ashwini Puniyamurti, Vincent Chow, Sunil K. Lal
    TLDR SARS-CoV-2 proteins help the virus avoid the immune system, delaying response and increasing inflammation.
    The review discussed the roles of SARS-CoV-2 non-structural proteins (NSPs) in evading host immune responses, which facilitated viral replication and increased disease severity. Key NSPs, such as NSP1, NSP3, and NSP5, were highlighted for their ability to inhibit host translation, suppress interferon production, and impair immune signaling pathways. The study emphasized the importance of understanding these mechanisms to develop potential therapeutic strategies, including drug repositioning and designing new antiviral agents. Despite vaccine development, the emergence of new variants posed challenges, underscoring the need for effective antivirals targeting these NSPs. Various compounds, such as Montelukast and Ivermectin, were identified as potential inhibitors to counteract these immune evasion tactics.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results