Safety Profile of Human Papilloma Virus Vaccines: An Analysis of the US Vaccine Adverse Event Reporting System from 2007 to 2017

    December 2018 in “ British Journal of Clinical Pharmacology ”
    Giulia Bonaldo, Alberto Vaccheri, Ottavio D’Annibali, Domenico Motola
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    TLDR HPV vaccines are generally safe but need further investigation for rare side effects.
    The document from January 21, 2019, analyzed the safety profile of HPV vaccines over a decade (2007-2017) using the US Vaccine Adverse Event Reporting System (VAERS). It found 55,356 reports of adverse events following immunization (AEFI) with HPV vaccines, with the majority related to Gardasil®. The most frequently reported events were dizziness and syncope, which were non-serious and listed in the vaccines' product characteristics. The study also noted potential safety signals for less frequent AEFIs like alopecia, hyperacusis, and parosmia that need further investigation. Additionally, it observed a correlation between Google® searches and AEFI reporting trends. Despite some new signals, the study concluded that HPV vaccines have a favorable risk-benefit profile, are sometimes used outside the recommended age range, and significantly reduce the risk of some cancers, reinforcing the importance of accurate vaccine safety information dissemination.
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