RPanglaoDB: An R Package to Download and Merge Labeled Single-Cell RNA-Seq Data from the PanglaoDB Database
July 2021
in “
Bioinformatics
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TLDR rPanglaoDB helps study rare cell types by merging RNA data, showing fibrocytes aid in healing.
The document introduced rPanglaoDB, an R package that facilitated the download and merging of single-cell RNA-seq data from the PanglaoDB database, aiding in the study of rare cell types by integrating multiple datasets. It enabled the collection and characterization of 157 fibrocytes, providing the first unbiased transcriptome profile of these cells, which have inflammatory and tissue remodeling properties. The study highlighted fibrocytes' role in healing processes through the activation of the prostaglandin biosynthesis and regulation pathway. The rPanglaoDB package showed potential for constructing atlases to characterize molecular phenotypes across various tissues and organisms.
