Roles of <scp>H</scp>ippo signaling pathway in size control of organ regeneration

The document discussed the role of the Hippo signaling pathway in controlling organ size during regeneration, particularly focusing on the transcriptional regulator Yap. It highlighted that while some species, like newts, could regenerate organs to their original size and shape, others could not fully restore lost parts. The Hippo pathway, through Yap, was believed to regulate organ size by sensing cell density, extracellular matrix contact, and cell position, thereby controlling gene expression. This mechanism explained how organ size was controlled during regeneration, preventing oversized or extra structures.